Methyl ester of 8-methoxy-2-phenylquinolin-4-carboxylic acid.



' qll whom it may concern:

UNITED srArEsA' MAX DOHBN, OF BERLIN, GERMANY, ASSIGTTOR T0 CHEM ISCHE FABRIK AUF ACTIEN' (YORM. E. scnnnmer'or BERLIN, GERMANY.

\ METHYL ESTER OF S-METHOXY-2-PHENYLQUINCvLIN--CABLBOXYLIC ACID.

No Drawing.

Patented Nov. 26, 1912.

Be it known that 1, MAX DOHRH, doctor of philosophy, chemist, citizen of the German Empire, residing at- BerIimGermany, have lnvented a new and useful Improve- 'ment in Methyl Esters of 8-Meth0Xy-2- stitution:

Phenylquinolinl-Carboxylic Acid, of which the following is a specification:

This invention relates to themanufacture of the methyl ester of 8-Inethoxy-2-phenylquinolinl-carboxylic acid, which is useful in the treatment of gout and articular rheumatism. The ester has the following con- It TOI'IIS pale yellow colored crystals and melts at about 102 C. and is soluble in alcohol, ether and benzene and forms salts 'esterification of the 8-methoxy-2-phenylquinolinl-carboxylic acid, for instance in the following way: 'Dry hydrochloric acid gas is passed for some hours through a niethylalcoholicsolution of 8-methoxy 2- phenylquinolin-4-carboxylic acid saturated in the cold with hydrochloric-acid. The solution is precipitated" with water, extracted with ether and the residuum of the ethereal solution recrystallized from alcohol.

I claim as my invention:

The herein described methyl ester of 8- methoxy-2-phenylquinolin4 carboxylic acid, melting at about 102 (3., forming pale yellow colored crystals,-being soluble in alcohol, ether and benzene, and forming salts, substantially as described.

In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses. A

- MAX DOHRN. Witnesses:

'IIENRY HASPER,

WOLDEMAR HAUPT. 

